![]() Studies – have also revealed that the amount of VF variability in glaucoma and other neuropathy was much higher than normal subjects. As visual field (VF) test is a psychophysical examination, previous investigation has reported that automated static perimetric threshold tests exhibit variability, within a test procedure and from one examination to another. In the present study we evaluated the sectoral pRNFL, the sectoral mGCIPL and average mGCIPL thickness in early stage glaucomatous optic neuropathy (EGON) and NGON eyes with comparable average pRNFL (aRNFL) loss, as well as normal controls to further characterize and distinguish the damage patterns of optic nerve and ganglion cell between the two different types of neuropathy. These studies indicated that both GON and non-glaucomatous optic neuropathy (NGON) could cause thinning of pRNFL and mGCIPL, but the pattern and extent of damage to pRNFL and mGCIPL seemed be different and warranted further study. Studies – about NAION and moderate to severe stage glaucoma revealed that although the average pRNFL and total macular thickness or mGCIPL thickness were similar, the mGCIPL damage location seemed different between the two types of neuropathy. They found that the highest relative change of pRNFL in eyes with multiple sclerosis was in the temporal quadrant, but the highest relative change of RNFL in glaucoma eyes was in the superior quadrant. Bock et al compared the pRNFL between multiple sclerosis with or without ON and glaucoma. Studies have indicated that pRNFL and mGCIPL measurements are useful in the early detection of GON these measurements have also been used to evaluate eyes associated with neuro-ophthalmic conditions, such as multiple sclerosis, ON, non-arteritis anterior ischemic optic neuropathy (NAION) and other optic neuropathies –. High-definition domain optical coherence tomography (HD-OCT) allows accurate and quantitative measurements of peripapillary retinal never fiber layer (pRNFL) thickness and macular ganglion cell plus inner plexiform layer (mGCIPL) thickness. Clinically, clues such as optic nerve head (ONH) pallor can be useful in discerning non-glaucomatous from glaucomatous optic nerve cupping however, in a study by Trobe et al experienced observers reviewed photographs of patients with glaucoma and mixed etiologies of non-glaucomatous optic nerve cupping and often misdiagnosed the etiology of the cupping and overestimated optic nerve pallor, indicating that differentiation between glaucomatous and non-glaucomatous cupping is difficult. Enlargement of optic disc cupping is most commonly associated with glaucomatous optic neuropathy (GON) but can also result from non-glaucomatous neurological lesions, such as optic neuritis (ON), ischemic optic neuropathy, hereditary optic neuropathy (HON), toxic optic neuropathy (TON), and compressive optic neuropathy (CON). Glaucoma is a chronic progressive optic neuropathy that causes irreversible damage to the optic nerve. While, compared to EGON group, the average mGCIPL of NGON group were significantly thinner, especially in superonasal and inferonasal sectors ( P<0.001). In EGON group the severest sites of mGCIPL reduction was located at inferotemporal and inferior sectors. The mGCIPL of EGON and NGON group were thinner than control group ( P<0.001). Compared to normal controls, the pRNFL thickness in all quadrants showed a decrease in both EGON and NGON group ( P0.05). ![]()
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